Brad Pitt caused quite the scandal in 2005 when he left wife Jennifer Aniston for his Mr. and Mrs. Smith leading lady, Angelina Jolie.
But he's not the first celeb to fall for a co-star while involved with someone else. Scroll through the gallery below to see which stars have ditched spouses and girlfriends for their onset partners!
The actor left longtime partner Mary-Louise Parker in 2003 — while she was seven months pregnant — for his Stage Beauty costar Claire Danes. They broke up in 2006.