She made audiences giggle with her performance as sex-crazed Sue Ann Nivens on The Mary Tyler Moore Show and followed that up with her portrayal of Rose Nylund on The Golden Girls. She continued to work after that show ended in 1992, but her big resurgence began in 2009 when she starred opposite Sandra Bullock and Ryan Reynolds in The Proposal — and a whole new generation fell in love with the hilarious actress. She now stars on the TV Land hit Hot in Cleveland.
These stars are living proof that once you've hit the bottom, the only way to go is up.
Scroll through to see the Hollywood comebacks no one will ever forget -- and make sure you don't miss the last slide considering it's someone you'd never think of!