Life & Style has exclusively learned that Angie returned home from a recent trip on behalf of the United Nations to find her husband acting strangely.
"The house was in disarray," an insider says. "[Brad was] glassy-eyed and out of it." When she confronted him, "He yelled back at her so loudly that his voice got hoarse."
The actor previously admitted as far back as 2011 that with six children, their home is always chaotic.
"Did you ever see the movie [One Flew Over the] Cuckoo's Nest? That's morning time in our house," the 52-year-old once joked with Ellen DeGeneres about the film set in a mental institution.
For more on Brangelina's divorce, pick up the latest issue of Life & Style, on newsstands now! And scroll through the gallery below for a look at what the key players have said so far.