Click through the gallery to see what they're up to now.
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Hugh Laurie (Dr. Gregory House)
The 56-year-old has been in a handful of episodes of HBO's show Veep and will star in the upcoming AMC series The Night Manager.
He's married to Jo Green and they have three kids together – Rebecca, 22, Charles, 27, and William, 21.
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Jesse Spencer (Dr. Robert Chase)
The 36-year-old plays Matthew Casey on NBC's Chicago Fire.
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Robert Sean Leonard (Dr. James Wilson)
The 46-year-old recently appeared in a few episodes of TNT's Falling Skies and NBC's Law & Order: SVU. Starting in February of next year he'll be starring in the Off Broadway theatrical production of Prodigal Son.
He's married to Gabriella Salick and they have two kids together – Eleanor, 6, and Claudia, 3.
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Jennifer Morrison (Dr. Allison Cameron)
The 36-year-old plays Emma Swan in ABC's Once Upon a Time and has a few new movies coming out next year, including 6 Miranda Drive with Kevin Bacon.
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Lisa Edelstein (Dr. Lisa Cuddy)
The 49-year-old has appeared in a few episodes of ABC's Castle and stars in Bravo's series Girlfriends' Guide to Divorce. Next year she'll be in the movie Joshy with Lauren Graham and Aubrey Plaza.
She married artist Robert Russell last year.
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Anne Dudek (Dr. Amber Volakis)
The 40-year-old has a few movies coming out next year, including The Waiting and House by the Lake.
She's married to Matthew Heller and they have two kids together – Saskia, 3, and Akiva, 7.
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Olivia Wilde (Dr. Remy 'Thirteen' Hadley)
The 31-year-old will star in the upcoming HBO series Vinyl, as well as the movie Black Dog, Red Dog with James Franco.
She's married to Jason Sudeikis, and they have a one-year-old son named Otis together.
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Kal Penn (Dr. Lawrence Kutner)
The 38-year-old is in the CBS series Battle Creek and will star in the upcoming Hulu series Deadbeat. He also has a handful of movies hitting theaters next year, including Going Under with Bruce Willis and John Goodman, and The Layover with Kate Upton.
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Peter Jacobson (Dr. Chris Taub)
The 61-year-old will star in the upcoming USA Network series Colony.
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Charlyne Yi (Dr. Chi Park)
The 29-year-old does the voice of Chloe in the Cartoon Network series We Bare Bears.
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Odette Annable (Dr. Jessica Adams)
The 30-year-old is on ABC's show The Astronaut Wives Club.
She and her husband Dave welcomed their first child together, a little girl named Charlie Mae, in September of this year.
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Omar Epps (Dr. Eric Foreman)
The 42-year-old is on ABC's show Resurrection and is currently filming the movie A Meyers Christmas with Gabrielle Union and Danny Glover.
He's married to Keisha and they have two kids together – Amir, 7, K'mari, 11. He has another child with his former girlfriend named Aiyanna, 15.
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Click through the gallery to see what the cast is up to now.