Click through the gallery to see what everyone's doing now (and to see how grown up Judd Apatow's daughters are!).
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Seth Rogen (Ben Stone)
The 33-year-old has a bunch of new movies coming out later this year and early next, including the holiday film The Night Before with Joseph Gordon-Levitt and Anthony Mackie. Next year his films Neighbors 2: Sorority Rising and Zeroville will hit theaters.
He's married to Lauren Miller, 33.
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Katherine Heigl (Alison Scott)
The 36-year-old starred in the NBC series State of Affairs last year, which unfortunately only lasted one season. She'll star in the movie Unforgettable with Rosario Dawson next year.
She's married to Josh Kelley, 35, and they have two kids together that they adopted – Nancy, 6, and Adalaide, 3.
The 43-year-old has a new movie coming out next year called How to Be Single with Dakota Johnson and Alison Brie. She'll also voice a character in the upcoming Croods 2 movie.
She's married to director/writer Judd Apatow, 47, and they have two kids together – Maude, 16, and Iris, 13.
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Paul Rudd (Pete)
The 46-year-old has a bunch of new movies coming out next year including The Revised Fundamentals of Caregiving with Selena Gomez and Captain America: Civil War.
He's married to Julie Yaeger and they have two children together – Darby, 5, and Jack, 9.
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Iris Apatow (Charlotte)
The 13-year-old is Leslie Mann and Judd Apatow's daughter. In 2012 she was in This Is 40 with her sister, mom, and Paul Rudd.
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Maude Apatow (Sadie)
The 16-year-old is also Leslie Mann and Judd Apatow's daughter. She's been in three episodes of Girls and will be in the movie Other People with Jesse Plemons and Molly Shannon.
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Jason Segel (Jason)
The 35-year-old starred in the movie The End of the Tour earlier this year with Jesse Eisenberg and was in Sex Tape with Cameron Diaz last year.
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Jay Baruchel (Jay)
The 33-year-old stars in the FXX show Man Seeking Woman and has a few movies coming out next year including Goon: Last of the Enforcers with Seann William Scott and Lovesick with Mad Men actress Jessica Paré.
He's married to actress Alison Pill, 29.
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Jonah Hill (Jonah)
The 31-year-old has a handful of movies coming out next ear including 23 Jump Street and Hail, Caesar! with Channing Tatum.
He's dating nutritionist Brooke Glazer.
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Martin Starr (Martin)
The 33-year-old has two movies coming out next year including Grow House and Operator with Mae Whitman.
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Charlyne Yi (Jodi)
The 29-year-old just released her first book Oh the Moon earlier this month.