Get ready to break out the tissues, y’all! On Sept. 26, ABC will be airing A Million Little Things, also known as: Everyone’s soon-to-be-favorite fall drama. Based on the official trailer, the series is about love, friendship, and death. Which, let’s face it, is the holy trinity of network television. This Is Us… never heard of ’em!

Beyond the riveting thematic elements, the cast of A Million Little Things is totally star-studded. There’s no doubt that you’ll be able to recognize these actors and actresses from some of your favorite movies and television shows. Keep scrolling to meet the cast and be sure to catch the premiere of A Million Little Things on Wednesday, Sept. 26th at 10 p.m. on ABC.