Celebrities Who’ve Admitted to Trying Ozempic, Wegovy & Other GLP-1 Weight Loss Drugs

Amy Schumer

Amy was one of the first celebrities to openly discuss a negative experience.

On Watch What Happens Live, she said she was “one of those people that felt so sick” taking Ozempic — but in 2025 revealed she’s now having “a really good experience” with Mounjaro and hormone replacement therapy for perimenopause.

Serena Williams

After welcoming her second child, the tennis icon revealed in 2025 that she turned to Zepbound when healthy eating and fitness weren’t enough.

“I knew my body was missing something it needed. For me, the answer was GLP-1s,” Williams said.

As an ambassador for Ro, she emphasized that medication is just one piece of the puzzle. “I feel like I have a lot of energy and it’s great. I just feel pretty good about it,” she added.

Meghan Trainor

The Grammy winner and husband Daryl Sabara approached weight loss as a team, combining the lowest dose of Mounjaro with a dietitian, exercise, and healthier routines.

“No, I don’t look like I did 10 years ago,” she wrote on Instagram after fans commented on her transformation.
“I’ve worked with a dietitian, made huge lifestyle changes, started exercising with a trainer, and yes, I used science and support (shoutout to Mounjaro!) to help me after my 2nd pregnancy. And I’m so glad I did because I feel great.”

Rebel Wilson

Rebel famously called 2020 her “Year of Health,” losing 77 pounds — but later used Ozempic to help maintain those results.

“Someone like me could have a bottomless appetite for sweets, so I think those drugs can be good,” she said in 2024, noting she’s no longer on GLP-1s and is comfortable with her current “still curvy and solid” weight.

Whoopi Goldberg

In 2024, Whoopi shared that Mounjaro played a major role in her weight loss after steroids contributed to a nearly 300-pound peak.

“I will tell you, I weighed almost 300 lb when I made [the 2022 film] Till. I had taken all those steroids, I was on all this stuff, and one of the things that’s helped me drop the weight was the Mounjaro. That’s what I useed.”

Kathy Bates

The Oscar winner credits lifestyle changes and Ozempic for helping her lose 100 pounds over seven years, with the last 20 coming after her type 2 diabetes diagnosis.

“It was hard work … especially during the pandemic,” said Bates.

Elon Musk

The billionaire made headlines when asked about his slimmed-down appearance in 2022.

“What’s your secret?” a fan wrote. Musk credited “fasting and Wegovy,” later calling GLP-1s one of the biggest public health opportunities, saying making them affordable “would do more to improve the health, lifespan, and quality of life for Americans” than almost anything else.

Chelsea Handler

Chelsea didn’t even realize she was taking Ozempic at first.

“My anti-aging doctor just hands it out to anybody,” she said on Call Her Daddy.
“I didn’t even know I was on it.” After discovering she’d been prescribed semaglutide, she stopped taking the medication.

Lizzo

On the Just Trish podcast, Lizzo said she has tried GLP-1s — but ultimately shifted her strategy.

“I’ve tried everything. It’s just the science, for me, calories in vs. calories out. Ozempic works because you eat less food. It makes you feel full. So, if you can just do that on your own and get mind-over-matter, it’s the same.”

Eric Stonestreet

The Modern Family star called Mounjaro life-changing.

“It’s a game changer. It has just been incredible. It’s changed my lifestyle, changed my approach to eating, changed my approach to exercise.”

He added that taking the drug motivated him to follow through with healthier habits. “I felt like, well, if I don’t do something along with it, I’m disappointing it. … when you make some really great choices, weight loss is also a byproduct of that.”