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Amy Schumer Praises Weight Loss Drug Mounjaro After ‘Horrible Experience’ With Wegovy
Amy Schumer has found the right weight loss medication that works for her after experiencing horrible nausea while previously taking Wegovy.
The comedian, 43, opened up about her experience taking Mounjaro in a recent Instagram Reel she posted on March 22.
“Three years ago I tried Wegovy and I was, like, puking. I couldn’t handle it. I don’t know if they’ve changed the formula. Whatever,” Amy began. “But anyway, I went on this telehealth meeting with Midi Health, and it was cheap. I wanted to try it myself because I wanted to recommend it to, like, my friends who were, like, nurses and teachers.”
She continued, “Mounjaro’s been great, and look, it’s not covered by insurance unless you have diabetes or severe obesity, which most of the internet thinks I have, but I’m having a really good experience with it and I wanted to keep it real with you about that.”
Weight loss drugs like Ozempic and Mounjaro have risen in popularity over the last few years, and they were initially used to help with type 2 diabetes. However, it was soon discovered that the active ingredient, semaglutide, also helped with weight loss. Wegovy also had the same effect, but its active ingredient was tirzepatide.
Amy has previously been open about how sick she was while taking Ozempic, but she also explained that it might have been caused by a specific gene.

“I have this gene – GDF15 – which makes you extremely prone to nausea, which is why I was so sick during my pregnancy,” the I Feel Pretty star said during an appearance on The Howard Stern Show on January 29. “So, I tried Ozempic almost three years ago, and I was, like, bedridden. I was like vomiting, and then you have no energy. But other people take it, and they’re all good.”
Howard, 71, who admitted that he “hates” the drug because he “tries so hard to be thin,” joked that he was happy when he heard it made Amy sick.
“I was so hopeful when I heard that you said, ‘Oh, it made me sick.’ I went, ‘Oh good!’ because everyone’s going to get sick on it and I’ll be back to being the only one who’s thin,” the Private Parts actor teased. “Every day you read something new about it like how it prevents Alzheimer’s, it gives you superpowers.”
Amy continued, “No, I tried it and I was vomiting and in bed and my son’s like, ‘Can you play tag?’ and I’m like, ‘I can’t.’ I was, like, shriveling away. I lost 30 pounds so quick, and I looked great, but I couldn’t lift my head off the pillow so, what’s the point?”
The Trainwreck star has never been one to mince words when it came to her weight and the criticism she’s received.
“I think they’re mad that I’m not thinner. I think they’re mad I’m not prettier and that I still feel like I have a right to speak,” she said during a February 2024 appearance on the “Not Skinny But Not Fat” podcast. “It’s been a long time people have been coming for me. So yeah, it’s just about how I’m feeling about myself.”
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