What makes Mila Kunis and Kate Bosworth so unique? They suffer from heterochromia — which means one's eyes are two different colors!

OK, so they're not in pain or anything, buuut it is technically a disease. A beautifully, mismatched one at that given these gals are nothing short of stunning.

And like these two Hollywood leading ladies, these six other stars in the gallery above know a thing or two about having different colored irises!