This means war!

Khloé Kardashian took to Twitter on Wednesday to slam critics after they accused her of disrespectful behavior towards estranged husband Lamar Odom. The 31-year-old was criticized for having multiple men in her life after she commented on boyfriend James Harden's latest basketball game.

RELATED: Khloé Kardashian Cancels Book Signing Due to Mysterious Illness

khloe and lamar

"You can't be with harden and still be married fam, gotta chose one," one user wrote. And another chimed in with, "For better or worse sickness and health till death do them part. I'm with you she needs to pick one or the ou (sic)."

Khloé fired back immediately, hinting at her complicated relationship with the former Laker, 36.

RELATED: Khloé Kardashian Won't Tell Lamar Odom How He Got His Brain Injury

The new author eventually stopped the drama to engage with fans who were praising her new book, Strong Looks Better Naked, before going offline completely.

Khloé has maintained a near-constant vigil at Lamar's bedside after he was found unconscious in a Nevada brothel last month. The stress of Lamar's health scare caused the former lovebirds to call off their divorce in October, with Khloé choosing to focus her efforts on his recovery.

Sounds like Khlo needs a break from social media!